Wille CK, Sridharan R. DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome. Stem Cell Reports. 2022 Feb 8;17(2):384-396. doi: 10.1016/j.stemcr.2021.12.004. Epub 2022 Jan 6. PMID: 34995500; PMCID: PMC8828533.


Zaidan NZ, Sridharan R. HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells. Nucleic Acids Res. 2020 Dec 16;48(22):12660-12674. doi: 10.1093/nar/gkaa1091. PMID: 33237287; PMCID: PMC7736818.

Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F. Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. Cell Metab. 2020 Apr 7;31(4):822-836.e5. doi: 10.1016/j.cmet.2020.03.002. Epub 2020 Mar 26.PMID: 32220307

Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM. Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Mol Cell. 2020 Apr 16;78(2):210-223.e8. doi: 10.1016/j.molcel.2020.03.004. Epub 2020 Mar 23.PMID: 32208170


Tran KA, Dillingham CM, Sridharan R. Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity. EMBO J. 2019 Nov 15;38(22):e101681. doi: 10.15252/embj.2019101681. Epub 2019 Oct 4.PMID: 31583744

Tran KA, Pietrzak SJ, Zaidan NZ, Siahpirani AF, McCalla SG, Zhou AS, Iyer G, Roy S, Sridharan R. Defining Reprogramming Checkpoints from Single-Cell Analyses of Induced Pluripotency. Cell Rep. 2019 May 7;27(6):1726-1741.e5. doi: 10.1016/j.celrep.2019.04.056.PMID: 31067459

Tran KA, Dillingham CM, Sridharan R. The role of α-ketoglutarate-dependent proteins in pluripotency acquisition and maintenance. J Biol Chem. 2019 Apr 5;294(14):5408-5419. doi: 10.1074/jbc.TM118.000831. Epub 2018 Sep 4.PMID: 30181211 


Zaidan NZ, Walker KJ, Brown JE, Schaffer LV, Scalf M, Shortreed MR, et al. Compartmentalization of HP1 proteins in pluripotency acquisition and maintenance. Stem cell reports. Elsevier; 2018 Jan 19.


Buxton KE, Kennedy-Darling J, Shortreed MR, Zaidan NZ, Olivier M, Scalf M, Sridharan R, Smith LM. Elucidating protein-DNA interactions in human alphoid chromatin via hybridization capture and mass spectrometry.J Proteome Res. 2017 Sep 1;16(9):3433-3442. doi: 10.1021/acs.jproteome.7b00448. Epub 2017 Aug 4. PMID: 28704058

Roy S, Sridharan R. Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes. Genome Res. 2017 Jul;27(7):1250-1262.


Jackson, S.A. *, Olufs, Z.P.G. *, Tran, K.A., Zaidan, N.Z., and Sridharan, R. Alternative routes to induced pluripotent stem cells revealed by reprogramming of neural lineage.  Stem Cell Reports 2016 Mar 8;6(3):302–11.* co-first authors.


Roy, S. *, Siahpirani, A.F., Knaack, S., Stewart, R., Wilson, M., Sridharan, R. Predictive framework for cell-line specific enhancer-promoter interactions defines signatures of long and short range regulation. Nucleic Acids Research 43 (18): 8694-8712. * corresponding author.

Tran KA, Jackson SA, Olufs ZPG, Zaidan NZ, Leng N, Kendziorski C, et al. Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways. Nat Commun. Nature Publishing Group; 2015 Feb 4;6:6188.


Sridharan R, Gonzales-Cope M, Chronis C, Bonora G, McKee R, Huang C, et al. Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nature cell biology. Nature Research; 2013 Jul 1;15(7):872–82.

Britton L-MP, Newhart A, Bhanu NV, Sridharan R, Gonzales-Cope M, Plath K, et al. Initial characterization of histone H3 serine 10 O-acetylation. Epigenetics. Landes Bioscience; 2013;8(10):1101–13.

Jackson SA, Sridharan R. The nexus of Tet1 and the pluripotency network. Cell stem cell. 2013 Apr;12(4):387–8.

Jackson SA, Sridharan R. Peering into the black box of reprogramming to the pluripotent state. Current Pathobiology Reports. Springer; 2013;1(2):129–36.


Sridharan R, Plath K. Small RNAs loom largeduring reprogramming. Cell stem cell. 2011 Jun;8(6):599–601.

Lin JJ, Lehmann LW, Bonora G, Sridharan R, Vashisht AA, Tran N, et al. Mediator coordinates PIC assembly with recruitment of CHD1. Genes development. Cold Spring Harbor Lab; 2011;25(20):2198–209.


Sridharan R*, Tchieu J*, Mason MJ*, Yachechko R, Kuoy E, Horvath S, et al. Role of the murine reprogramming factors in the induction of pluripotency. * equal contribution. Cell. 2009 Jan;136(2):364–77.

Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, Heidersbach A, et al. Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature. Nature Publishing Group; 2009 Aug 13;460(7257):863–8.

Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, et al. Histone H3 Lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell. 2009 Feb;33(4):417–27.


Lowry WE, Richter L, Yachechko R, Pyle AD, Tchieu J, Sridharan R, et al. Generation of human induced pluripotent stem cells from dermal fibroblasts. PNAS. 2008 Feb 26;105(8):2883–8.

Sridharan R, Plath K. Illuminating the black box of reprogramming. Cell stem cell. 2008 Apr;2(4):295–7.


Sridharan R, Smale ST. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology; 2007 Oct 12;282(41):30227–38.

Maherali, N.*, Sridharan, R.*, Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu. J., Jaenisch, R., Plath, K.#, and Hochedlinger, K.#. Global epigenetic remodeling in directly reprogrammed fibroblasts.* equal contribution;  # co-corresponding authors. 2007 Cell Stem Cell, 1(1): 55-70.


Ramirez-Carrozzi VR, Nazarian AA, Li CC, et al. Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory responseGenes & Development. 2006;20(3):282-296.


Su, R. C., Sridharan, R., and Smale, S.T.  Assembly of silent chromatin during thymocyte development. Semin Immunol 2005; 17(2):129-40.


Papathanasiou, P., Perkins, A. C., Cobb, B. S., Ferrini, R., Sridharan, R., Hoyne, G. F., Nelms, K. A., Smale, S.T., and Goodnow,C.C. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.  Immunity  2003;  19(1):131-44.